GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7692995 | 1 | rs6850259 | chr4:17949607 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.36 | 1.59E-5 | Height |
| THCA | cis | rs7692995 | 1 | rs6850306 | chr4:18006089 | DCAF16 | chr4:17802280-17812381:- | -0.22 | -4.37 | 1.54E-5 | Height |
| THCA | cis | rs7664683 | 1 | rs6850893 | chr4:103254421 | BANK1 | chr4:102341118-102995967:+ | -0.24 | -3.4 | 0.000742 | Erythrocyte cadmium concentration in never smokers |
| THCA | cis | rs6832769 | 1 | rs6851838 | chr4:56420747 | TMEM165 | chr4:56262090-56292342:+ | 0.16 | 3.98 | 8.05E-5 | Personality dimensions |
| THCA | cis | rs6832769 | 1 | rs6853192 | chr4:56409254 | TMEM165 | chr4:56262090-56292342:+ | 0.16 | 3.89 | 0.000114 | Personality dimensions |
| THCA | cis | rs7692995 | 1 | rs6853216 | chr4:17970655 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.45 | 1.06E-5 | Height |
| THCA | cis | rs17030434 | 1 | rs6853522 | chr4:154706220 | RNF175 | chr4:154631313-154681387:- | 0.2 | 4.21 | 3.0E-5 | Electrocardiographic conduction measures |
| THCA | cis | rs11734488 | 1 | rs6854381 | chr4:139130390 | SLC7A11 | chr4:139085248-139163503:- | 0.22 | 4.49 | 9.06E-6 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |
| THCA | cis | rs4691139 | 1 | rs6855591 | chr4:165906723 | C4orf39 | chr4:165878100-165880273:+ | 0.18 | 5.04 | 6.62E-7 | Ovarian cancer in BRCA1 mutation carriers |
| THCA | cis | rs2412488 | 1 | rs6857024 | chr4:54242283 | SCFD2 | chr4:53739152-54232242:- | 0.2 | 3.76 | 0.000189 | DNA methylation (variation) |
| THCA | cis | rs6878284 | 1 | rs6859811 | chr5:101663195 | SLCO4C1 | chr5:101569694-101632253:- | 0.25 | 5.65 | 2.77E-8 | Schizophrenia |
| THCA | cis | rs6878284 | 1 | rs6860381 | chr5:101663536 | SLCO4C1 | chr5:101569694-101632253:- | 0.25 | 5.65 | 2.77E-8 | Schizophrenia |
| THCA | cis | rs6860540 | 1 | rs6860540 | chr5:156938327 | NIPAL4 | chr5:156887027-156901729:+ | -0.33 | -6.82 | 2.75E-11 | Inflammatory skin disease |
| THCA | cis | rs6861497 | 1 | rs6861497 | chr5:101403586 | SLCO4C1 | chr5:101569694-101632253:- | -0.18 | -4 | 7.25E-5 | QRS duration |
| THCA | cis | rs6878284 | 1 | rs6862270 | chr5:101701227 | SLCO4C1 | chr5:101569694-101632253:- | 0.25 | 5.67 | 2.5E-8 | Schizophrenia |